Division of Carbohydrate Chemistry

ACS CARB

Steve.Sucheck@UToledo.edu


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Joined Mar 25 2010
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Division of Carbohydrate Chemistry

Recent Activity
About Me

Education and Experience

2005-Present Associate Professor of Chemistry, University of Toledo

Group Website

2003-2005 Group Leader, Optimer Pharmaceuticals, Inc.

2000-2002 Sr. Scientist, Optimer Pharmaceuticals, Inc.

1998-2000 NIH Postdoctoral Fellow, The Scripps Research Institute

Research: Bifunctional Aminoglycoside Antibiotics

Research Supervisor: Professor Chi-Huey Wong

1998 Ph.D., Chemistry, University of Virginia

Thesis: Study of DNA Interactive Agents

Research Supervisor: Professor Sidney M. Hecht

1992 B.S., Chemistry, University of Toledo

Research Synopsis:

In general, our laboratory is interested in synthetic investigations useful for defining the structure-function relationships of natural or designed ligands in an effort to better understand the origin of their biological properties.

Specific areas of interest include:

(1) New synthetic strategies for the preparation of homogeneous glycopeptides.

(2) Glycopeptide-based cancer diagnostics and vaccines.

(3) Synthetic investigations into new antibiotics.

Recent Publications (of 33)

Sarkar, S.; Sayler, A. C. D.; Wall, K. A.; Sucheck, S. J. Synthesis and immunological evaluation of a MUC1 glycopeptide incorporated into L-rhamnose displaying liposomes. Bioconjugate. Chem. Submitted.

Ibrahim, D. A.; Boucau, J.; Lajiness, D. H.; Veleti, S. K.; Trabbic, K. R.; Adams, S. S. Ronning, D. R.; Sucheck S. J. Design, synthesis and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis Antigen 85C. Bioconjugate Chem. 2012, 23, 2403–2416.

Gaitonde, V. and Sucheck S. J. Synthesis of β-Glycosyl amides from N-glycosyl dinitrobenzenesulfonamides J. Carbohydr. Chem. 2012, 31, 433–450.

Karmakar, P.; Talan, S. R.; Sucheck, S. J. Mixed-phase synthesis of glycopeptides using a N-peptidyl-2,4-dinitrobenzenesulfonamide-thioacid ligation strategy. Org. Lett. 2011 Org. Lett. 2011, 13, 5298–5301.

Sarkar, S.; Sucheck S. J. Comparing the use of 2-methylenenapthyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl and 2,4,6-trimethoxybenzyl as N–H protecting groups for p-tolyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-beta-D-glucosides. Carbohydr. Res. 2011, 346, 393–400.

Sarkar, S.; Lombardo, S. A.; Herner, D. N.; Talan, R. S.; Wall, K. A.; Sucheck S. J. Synthesis of a single molecule L-rhamnose-containing three component vaccine and evaluation of antigenicity in the presence of anti L-rhamnose antibodies. J. Am. Chem. Soc. 2010, 132, 17236–17246.

Umesiri, F. E.; Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Recent advances towards the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis. Med. Res. Rev. 2010, 30, 290-326.

Talan, R. S.; Sanki, A. K.; Sucheck, S. J. Facile synthesis of N-glycosyl amides using a N-glycosyl-2,4-dinitrobenzenesulfonamide and thioacids. Carbohydr. Res. 2009, 344, 2048-2050.

Sanki, A. K.; Boucau, J.; Umesiri, F. E.; Ronning, D. R.; Sucheck, S. J. Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Mol. BioSyst. 2009, 5, 945-956.

Ragupathi, G.; Damani, P.; Srivastava, G.; Srivastava, O.; Sucheck, S. J.; Ichikawa, Y.; Livingston, P. O. Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine. Cancer Immunol. Immunother. 2009, 58, 1397-1405.

Sanki, A. K.; Talan, R. S.; Sucheck, S. J. Synthesis of small glycopeptides by decarboxylative condensation and insight into the reaction mechanism. J. Org. Chem. 2009, 74, 1886-1896.

Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan. Glycoconjugate J. 2009, 26, 589-596.

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